Ultrafiltration of plasma during formation of the primary urine in the glomeruli is a major
function of the kidney. The glomerulus is a tuft of anastomosing capillaries located within
Bowman's capsule. The glomerular capillary wall has a complex morphology that facilitates
a unique filtration function. This filtration barrier consists of three layers: a fenestrated
endothelium, the glomerular basement membrane (GBM), and the outermost epithelial
podocyte foot processes with their interconnecting slit diaphragms. Despite rapidly …