Phagocytes and oxidative stress
BM Babior - The American journal of medicine, 2000 - Elsevier
Neutrophils and other phagocytes manufacture O2−(superoxide) by the one-electron
reduction of oxygen at the expense of NADPH. Most of the O2− reacts with itself to form
H2O2 (hydrogen peroxide). From these agents a large number of highly reactive
microbicidal oxidants are formed, including HOCl (hypochlorous acid), which is produced by
the myeloperoxidase-catalyzed oxidation of Cl− by H2O2; OH·(hydroxyl radical), produced
by the reduction of H2O2 by Fe++ or Cu+; ONOO−(peroxynitrite), formed by the reaction …
reduction of oxygen at the expense of NADPH. Most of the O2− reacts with itself to form
H2O2 (hydrogen peroxide). From these agents a large number of highly reactive
microbicidal oxidants are formed, including HOCl (hypochlorous acid), which is produced by
the myeloperoxidase-catalyzed oxidation of Cl− by H2O2; OH·(hydroxyl radical), produced
by the reduction of H2O2 by Fe++ or Cu+; ONOO−(peroxynitrite), formed by the reaction …
