Involvement of multiple transcription factors in the regulation of steroidogenic acute regulatory protein gene expression
PR Manna, XJ Wang, DM Stocco - Steroids, 2003 - Elsevier
The rate-limiting, committed, and regulatable step in steroid hormone biosynthesis is the
transport of cholesterol from the outer to the inner mitochondrial membrane, a process that is
mediated by the steroidogenic acute regulatory (StAR) protein. In steroidogenic cells, the
StAR protein is regulated by cAMP-dependent mechanisms. However, the StAR promoter
lacks a consensus cAMP response-element (CRE), suggesting the involvement of alternate
regulatory factor (s) in cAMP responsiveness. These regulatory elements are found to be …
transport of cholesterol from the outer to the inner mitochondrial membrane, a process that is
mediated by the steroidogenic acute regulatory (StAR) protein. In steroidogenic cells, the
StAR protein is regulated by cAMP-dependent mechanisms. However, the StAR promoter
lacks a consensus cAMP response-element (CRE), suggesting the involvement of alternate
regulatory factor (s) in cAMP responsiveness. These regulatory elements are found to be …
