Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial
K Esposito, A Pontillo, C Di Palo, G Giugliano… - Jama, 2003 - jamanetwork.com
ContextObesity is an independent risk factor for cardiovascular disease, which may be
mediated by increased secretion of proinflammatory cytokines by adipose tissue.
ObjectiveTo determine the effect of a program of changes in lifestyle designed to obtain a
sustained reduction of body weight on markers of systemic vascular inflammation and
insulin resistance. Design and SettingRandomized single-blind trial conducted from
February 1999 to February 2002 at a university hospital in Italy. PatientsOne hundred twenty …
mediated by increased secretion of proinflammatory cytokines by adipose tissue.
ObjectiveTo determine the effect of a program of changes in lifestyle designed to obtain a
sustained reduction of body weight on markers of systemic vascular inflammation and
insulin resistance. Design and SettingRandomized single-blind trial conducted from
February 1999 to February 2002 at a university hospital in Italy. PatientsOne hundred twenty …
