Mucosal inflammation and more recently airway remodeling continue to be a focus of
interest when considering both the pathophysiology and treatment of asthma. Although a
number of candidate genes relevant to inflammatory cell action have been identified and
linked to atopy and airway hyperresponsiveness, it is important to understand genetic factors
that might determine the extent of tissue remodeling. The mechanisms regulating the allergic
responses in the airways are complex, involving antigen presenting cells and T …