[HTML][HTML] Intrinsic regulation of the interactions between the SH3 domain of p85 subunit of phosphatidylinositol-3 kinase and the protein network of BCR/ABL oncogenic …
S Ren, F Xue, J Feng, T Skorski - Experimental hematology, 2005 - Elsevier
OBJECTIVE: BCR/ABL fusion tyrosine kinase is responsible for the initiation and
maintenance of the Philadelphia chromosome-positive chronic myelogenous leukemia
(CML) and a cohort of acute lymphocytic leukemias. We show that a signaling protein,
phosphatidylinositol-3 kinase (PI-3k), is essential for growth of CML cells, but not of normal
hematopoietic cells, and that p85α subunit of PI-3k co-immunoprecipitates with BCR/ABL.
Therefore, we made an attempt to better characterize p85α–BCR/ABL interactions …
maintenance of the Philadelphia chromosome-positive chronic myelogenous leukemia
(CML) and a cohort of acute lymphocytic leukemias. We show that a signaling protein,
phosphatidylinositol-3 kinase (PI-3k), is essential for growth of CML cells, but not of normal
hematopoietic cells, and that p85α subunit of PI-3k co-immunoprecipitates with BCR/ABL.
Therefore, we made an attempt to better characterize p85α–BCR/ABL interactions …