Pressure stimulates breast cancer cell adhesion independently of cell cycle and apoptosis regulatory protein (CARP)-1 regulation of focal adhesion kinase
C Downey, K Alwan, V Thamilselvan, L Zhang… - The American journal of …, 2006 - Elsevier
BACKGROUND: Pressure stimulates colon cancer adhesion via focal adhesion kinase
(FAK). Extracellular pressures reaching 29 mm Hg have been reported in rapidly growing
breast cancers, and tumors experience pressure during surgical manipulation. We
hypothesized that pressure stimulates breast cancer adhesion and that CARP-1, which
influences cancer biology, inhibits FAK, and modulates pressure effects. METHODS: We
compared MDA-MB-468 breast cancer cells under ambient or 15-mm Hg increased …
(FAK). Extracellular pressures reaching 29 mm Hg have been reported in rapidly growing
breast cancers, and tumors experience pressure during surgical manipulation. We
hypothesized that pressure stimulates breast cancer adhesion and that CARP-1, which
influences cancer biology, inhibits FAK, and modulates pressure effects. METHODS: We
compared MDA-MB-468 breast cancer cells under ambient or 15-mm Hg increased …
