Downregulation of prolactin-releasing peptide gene expression in the hypothalamus and brainstem of diabetic rats
T Mera, H Fujihara, J Saito, M Kawasaki, H Hashimoto… - Peptides, 2007 - Elsevier
We investigated the prolactin-releasing peptide (PrRP) mRNA levels in the hypothalamus
and brainstem of streptozotocin (STZ)-induced diabetic rats and fa/fa Zucker diabetic rats,
using in situ hybridization histochemistry. PrRP mRNA levels in the hypothalamus and
brainstem of STZ-induced diabetic rats were significantly reduced in comparison with those
of control rats. PrRP mRNA levels in the diabetic rats were reversed by both insulin and
leptin. PrRP mRNA levels in the fa/fa diabetic rats were significantly reduced in comparison …
and brainstem of streptozotocin (STZ)-induced diabetic rats and fa/fa Zucker diabetic rats,
using in situ hybridization histochemistry. PrRP mRNA levels in the hypothalamus and
brainstem of STZ-induced diabetic rats were significantly reduced in comparison with those
of control rats. PrRP mRNA levels in the diabetic rats were reversed by both insulin and
leptin. PrRP mRNA levels in the fa/fa diabetic rats were significantly reduced in comparison …