Expressions of the prepro-orexin and orexin type 2 receptor genes in obese rat

Y Yamamoto, Y Ueta, H Yamashita, K Asayama… - Peptides, 2002 - Elsevier
We examined the expressions of the prepro-orexin gene in the lateral hypothalamic area
(LHA), the genes of the neuropeptide Y (NPY) and proopiomelanocortin (POMC) in the
arcuate nucleus (ARC), the orexin type 1 receptor (OX1R) gene in the ventromedial
hypothalamic nucleus (VMH) and the orexin type 2 receptor (OX2R) gene in the
paraventricular nucleus (PVN) in 6-, 12-and 18-week-old male lean (Fa/?) and obese (fa/fa)
Zucker rats, using in situ hybridization histochemistry. The fa/fa rats showed hyperglycemia …