Increased infarct size in uremic rats: reduced ischemia tolerance?
R Dikow, LP Kihm, M Zeier, J Kapitza, J To… - Journal of the …, 2004 - journals.lww.com
In patients with renal failure, myocardial infarction (MI) is more frequent and the rate of death
from acute MI is very high. It has been argued that ischemia tolerance of the heart is reduced
in uremia, but direct evidence for this hypothesis has not been provided. It was the purpose
of this study (1) to ligate the left coronary artery and to measure the nonperfused area (risk
area: total infarction plus penumbra) as well as the area of total infarction in subtotally
nephrectomized (SNX) rats compared with sham-operated pair-fed control rats and (2) to …
from acute MI is very high. It has been argued that ischemia tolerance of the heart is reduced
in uremia, but direct evidence for this hypothesis has not been provided. It was the purpose
of this study (1) to ligate the left coronary artery and to measure the nonperfused area (risk
area: total infarction plus penumbra) as well as the area of total infarction in subtotally
nephrectomized (SNX) rats compared with sham-operated pair-fed control rats and (2) to …