[HTML][HTML] Induction of angiotensin I-converting enzyme transcription by a protein kinase C-dependent mechanism in human endothelial cells
E Villard, A Alonso, M Agrapart, M Challah… - Journal of Biological …, 1998 - ASBMB
Angiotensin I-converting enzyme (ACE) has been implicated in various cardiovascular
diseases; however, little is known about the ACE gene regulation in endothelial cells. We
have investigated the effect of the protein kinase C activator phorbol 12-myristate 13-acetate
(PMA) on ACE activity and gene expression in human umbilical vein endothelial cells
(HUVEC). Our results showed a 3-and 5-fold increase in ACE activity in the medium and in
the cells, respectively, after 24-h stimulation by PMA. We also observed an increase in the …
diseases; however, little is known about the ACE gene regulation in endothelial cells. We
have investigated the effect of the protein kinase C activator phorbol 12-myristate 13-acetate
(PMA) on ACE activity and gene expression in human umbilical vein endothelial cells
(HUVEC). Our results showed a 3-and 5-fold increase in ACE activity in the medium and in
the cells, respectively, after 24-h stimulation by PMA. We also observed an increase in the …