Distant effects of experimental renal ischemia/reperfusion injury
KJ Kelly - Journal of the American Society of Nephrology, 2003 - journals.lww.com
Acute renal failure results in significant morbidity and mortality, yet renal failure is not the
usual cause of death in the clinical situation. We have previously reported systemic
increases in the inflammatory mediators tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-
1) after renal ischemia in the mouse. In the present study, an animal model of bilateral renal
ischemia was used to test the hypothesis that cytokines released with renal ischemia have
effects on other organ systems. Increased levels of immunoreactive TNF-α and IL-1 and …
usual cause of death in the clinical situation. We have previously reported systemic
increases in the inflammatory mediators tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-
1) after renal ischemia in the mouse. In the present study, an animal model of bilateral renal
ischemia was used to test the hypothesis that cytokines released with renal ischemia have
effects on other organ systems. Increased levels of immunoreactive TNF-α and IL-1 and …