[HTML][HTML] Modulation of Rho GTPase activity in endothelial cells by selective proteinase-activated receptor (PAR) agonists
V Vouret-Craviari, D Grall… - Journal of Thrombosis …, 2003 - Elsevier
The proteinase-activated receptors (PAR) PAR1 and PAR2 mediate responses to thrombin
and trypsin-like proteases, respectively. Both receptors are expressed on endothelial cells
where they have been reported to transduce a similar set of intracellular responses. In
cultured human umbilical vein endothelial cells (HUVEC), we observed a marked difference
in shape changes induced by PAR-activating peptides (PAR-APs); unlike PAR1-AP, PAR2-
AP failed to stimulate cell rounding. Objectives were to shed light on the mechanisms …
and trypsin-like proteases, respectively. Both receptors are expressed on endothelial cells
where they have been reported to transduce a similar set of intracellular responses. In
cultured human umbilical vein endothelial cells (HUVEC), we observed a marked difference
in shape changes induced by PAR-activating peptides (PAR-APs); unlike PAR1-AP, PAR2-
AP failed to stimulate cell rounding. Objectives were to shed light on the mechanisms …
