[HTML][HTML] Protease-activated receptors-1 and-2 can mediate endothelial barrier protection: role in factor Xa signaling
C Feistritzer, R Lenta, M Riewald - Journal of Thrombosis and Haemostasis, 2005 - Elsevier
Coagulation and inflammation are intimately linked and cellular signaling by coagulation
proteases through protease-activated receptors (PARs) may affect pro-and anti-inflammatory
responses. Permeability of the endothelial cell barrier at the blood–tissue interface plays a
key role in inflammatory disorders such as sepsis. We have recently shown that PAR1
signaling by activated protein C or low concentrations of thrombin can enhance endothelial
barrier integrity. In the present study, we analyzed effects of coagulation factor Xa (FXa) …
proteases through protease-activated receptors (PARs) may affect pro-and anti-inflammatory
responses. Permeability of the endothelial cell barrier at the blood–tissue interface plays a
key role in inflammatory disorders such as sepsis. We have recently shown that PAR1
signaling by activated protein C or low concentrations of thrombin can enhance endothelial
barrier integrity. In the present study, we analyzed effects of coagulation factor Xa (FXa) …
