A decade of CDK5
R Dhavan, LH Tsai - Nature reviews Molecular cell biology, 2001 - nature.com
R Dhavan, LH Tsai
Nature reviews Molecular cell biology, 2001•nature.comSince it was identified a decade ago, cyclin-dependent kinase 5 (CDK5) has emerged as a
crucial regulator of neuronal migration in the developing central nervous system. CDK5
phosphorylates a diverse list of substrates, implicating it in the regulation of a range of
cellular processes? from adhesion and motility, to synaptic plasticity and drug addiction.
Recent evidence indicates that deregulation of this kinase is involved in the pathology of
neurodegenerative diseases.
crucial regulator of neuronal migration in the developing central nervous system. CDK5
phosphorylates a diverse list of substrates, implicating it in the regulation of a range of
cellular processes? from adhesion and motility, to synaptic plasticity and drug addiction.
Recent evidence indicates that deregulation of this kinase is involved in the pathology of
neurodegenerative diseases.
Abstract
Since it was identified a decade ago, cyclin-dependent kinase 5 (CDK5) has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes ? from adhesion and motility, to synaptic plasticity and drug addiction. Recent evidence indicates that deregulation of this kinase is involved in the pathology of neurodegenerative diseases.
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