Expression and function of Ets-1 during experimental acute renal failure in rats
H Tanaka, Y Terada, T Kobayashi… - Journal of the …, 2004 - journals.lww.com
The Ets family of transcription factors is defined by a conserved DNA-binding Ets domain
that forms a winged helix-turn-helix structure motif. The Ets family is involved in a diverse
array of biologic functions, including cellular growth, migration, and differentiation. The
hypothesis in this study was that Ets-1 is re-expressed during regeneration after acute renal
failure (ARF) and plays a key role in the transcriptional regulation of cyclin D1 and the cell
cycle progression in renal tubular cells. For clarifying the significance of Ets-1 in ARF, a rat …
that forms a winged helix-turn-helix structure motif. The Ets family is involved in a diverse
array of biologic functions, including cellular growth, migration, and differentiation. The
hypothesis in this study was that Ets-1 is re-expressed during regeneration after acute renal
failure (ARF) and plays a key role in the transcriptional regulation of cyclin D1 and the cell
cycle progression in renal tubular cells. For clarifying the significance of Ets-1 in ARF, a rat …