[HTML][HTML] Phosphorylation of Ser-129 is the dominant pathological modification of α-synuclein in familial and sporadic Lewy body disease
JP Anderson, DE Walker, JM Goldstein… - Journal of Biological …, 2006 - ASBMB
A comprehensive, unbiased inventory of synuclein forms present in Lewy bodies from
patients with dementia with Lewy bodies was carried out using two-dimensional immunoblot
analysis, novel sandwich enzyme-linked immunosorbent assays with modification-specific
synuclein antibodies, and mass spectroscopy. The predominant modification of α-synuclein
in Lewy bodies is a single phosphorylation at Ser-129. In addition, there is a set of
characteristic modifications that are present to a lesser extent, including ubiquitination at Lys …
patients with dementia with Lewy bodies was carried out using two-dimensional immunoblot
analysis, novel sandwich enzyme-linked immunosorbent assays with modification-specific
synuclein antibodies, and mass spectroscopy. The predominant modification of α-synuclein
in Lewy bodies is a single phosphorylation at Ser-129. In addition, there is a set of
characteristic modifications that are present to a lesser extent, including ubiquitination at Lys …
