Cellular oligomerization of α-synuclein is determined by the interaction of oxidized catechols with a C-terminal sequence
JR Mazzulli, M Armakola, M Dumoulin… - Journal of biological …, 2007 - ASBMB
The mechanisms that govern the formation of α-synuclein (α-syn) aggregates are not well
understood but are considered a central event in the pathogenesis of Parkinson's disease
(PD). A critically important modulator of α-syn aggregation in vitro is dopamine and other
catechols, which can prevent the formation of α-syn aggregates in cell-free and cellular
model systems. Despite the profound importance of this interaction for the pathogenesis of
PD, the processes by which catechols alter α-syn aggregation are unclear. Molecular and …
understood but are considered a central event in the pathogenesis of Parkinson's disease
(PD). A critically important modulator of α-syn aggregation in vitro is dopamine and other
catechols, which can prevent the formation of α-syn aggregates in cell-free and cellular
model systems. Despite the profound importance of this interaction for the pathogenesis of
PD, the processes by which catechols alter α-syn aggregation are unclear. Molecular and …
