NF-κB and HIV: Linking viral and immune activation
AB Rabson, HC Lin - Advances in Pharmacology, 2000 - Elsevier
Human immunodeficiency virus (HIV) replication is critically dependent on the regulated
transcription of HIV RNAs, including both the full-length viral RNA that is packaged as the
viral genome in progeny virions and the array of unspliced and spliced mRNAs that encode
the different viral proteins (reviewed in Antoni, Stein, and Rabson, 1994). The regulation of
HIV RNA transcription is dependent on the functions of both the viral Tat transactivator
protein (see Chapter 10) as well as the activities of a series of cellular transcriptional factors …
transcription of HIV RNAs, including both the full-length viral RNA that is packaged as the
viral genome in progeny virions and the array of unspliced and spliced mRNAs that encode
the different viral proteins (reviewed in Antoni, Stein, and Rabson, 1994). The regulation of
HIV RNA transcription is dependent on the functions of both the viral Tat transactivator
protein (see Chapter 10) as well as the activities of a series of cellular transcriptional factors …
