ported to have higher geometric mean fasting homocyst (e) ine levels than C/T heterozygotes or C/C homozygotes when folate status was below the population median, but no differences in fasting homocyst (e) ine levels were detected between persons with different genotypes when plasma folate was at or above the population median. 29 The MTHFR genotype has been reported to influence the homocyst (e) ine response to folic acid. Reduction was greater in subjects with T/T than with C/C or C/T genotypes. 19 Moreover, in 21 of 37 subjects with homocyst (e) ine 40 mol/L, in whom the frequency of the T/T genotype was 92%, homocyst (e) ine levels were normalized with supplemental intake of folic acid as low as 200 g/d. 8 It is likely but not proven that a folate-rich diet ingested by subjects with the T/T genotype may be more effective in lowering homocyst (e) ine levels than a similar diet ingested by subjects with C/C or C/T genotypes.