Homocysteine has received increased attention over the past 2 decades within the scientific
community, and more recently among the lay public, for its unique role in a host of human
diseases. Of particular note, investigations into the biology of homocysteine have ultimately
revealed it as an independent and modifiable risk factor for vascular diseases, namely
coronary artery disease (CAD), cerebrovascular disease, and peripheral arterial disease [1,
2]. Interestingly, despite its well-defined structure and metabolism, and although laboratory …