[HTML][HTML] Elevated plasma homocysteine leads to alterations in fibrin clot structure and stability: implications for the mechanism of thrombosis in hyperhomocysteinemia
DL Sauls, AS Wolberg, M Hoffman - Journal of Thrombosis and …, 2003 - Elsevier
Elevated plasma homocysteine is associated with an increased risk of atherosclerosis and
thrombosis. However, the mechanisms by which homocysteine might cause these events
are not understood. We hypothesized that hyperhomocysteinemia might lead to modification
of fibrinogen in vivo, thereby causing altered fibrin clot structure. New Zealand White rabbits
were injected intraperitoneally (ip) every 12 h through an indwelling catheter with
homocysteine or buffer for 8 weeks. This treatment raised the plasma homocysteine levels to …
thrombosis. However, the mechanisms by which homocysteine might cause these events
are not understood. We hypothesized that hyperhomocysteinemia might lead to modification
of fibrinogen in vivo, thereby causing altered fibrin clot structure. New Zealand White rabbits
were injected intraperitoneally (ip) every 12 h through an indwelling catheter with
homocysteine or buffer for 8 weeks. This treatment raised the plasma homocysteine levels to …