[HTML][HTML] Transcriptional roles of CCAAT/enhancer binding protein-β, nuclear factor-κB, and C-promoter binding factor 1 in interleukin (IL)-1β-induced IL-6 synthesis by …
K Miyazawa, A Mori, K Yamamoto… - Journal of Biological …, 1998 - ASBMB
The involvement of interleukin (IL)-6 in the pathogenesis of rheumatoid arthritis (RA) has
been recently demonstrated. IL-1β stimulated rheumatoid fibroblast-like synoviocytes (FLSs)
to produce IL-6 in a concentration-and time-dependent manner. In the present study we
investigated how the IL-6 promoter is transcriptionally regulated in rheumatoid FLSs in
response to a physiologically relevant mediator of inflammation, IL-1β. Deletion analysis
showed that the IL-6 promoter is regulated by two positive elements (located at− 159 to− 142 …
been recently demonstrated. IL-1β stimulated rheumatoid fibroblast-like synoviocytes (FLSs)
to produce IL-6 in a concentration-and time-dependent manner. In the present study we
investigated how the IL-6 promoter is transcriptionally regulated in rheumatoid FLSs in
response to a physiologically relevant mediator of inflammation, IL-1β. Deletion analysis
showed that the IL-6 promoter is regulated by two positive elements (located at− 159 to− 142 …
