[HTML][HTML] Inhibition of apoptosis by Z-VAD-fmk in SMN-depleted S2 cells
R Ilangovan, WL Marshall, Y Hua, J Zhou - Journal of Biological Chemistry, 2003 - ASBMB
Spinal muscular atrophy is an autosomal recessive motor neuron degenerative disorder,
caused by the loss of telomeric copy of the survival motor neuron gene (SMN1). To better
understand how motor neurons are targeted in Spinal muscular atrophy patients, it is
important to study the role of SMN protein in cell death. In this report, we employed RNA
interference (RNAi) to study the loss-of-function of SMN in Drosophila S2 cells. A 601-base
pair double-stranded RNA (dsRNA) of Drosophila SMN (dSMN) was used for silencing the …
caused by the loss of telomeric copy of the survival motor neuron gene (SMN1). To better
understand how motor neurons are targeted in Spinal muscular atrophy patients, it is
important to study the role of SMN protein in cell death. In this report, we employed RNA
interference (RNAi) to study the loss-of-function of SMN in Drosophila S2 cells. A 601-base
pair double-stranded RNA (dsRNA) of Drosophila SMN (dSMN) was used for silencing the …
