CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice
BL Apostol, DA Simmons, C Zuccato, K Illes… - Molecular and Cellular …, 2008 - Elsevier
Huntington's disease (HD) is a devastating neurodegenerative disorder caused by an
expanded polyglutamine repeat within the protein Huntingtin (Htt). We previously reported
that mutant Htt expression activates the ERK1/2 and JNK pathways [Apostol, BL, Illes, K.,
Pallos, J., Bodai, L., Wu, J., Strand, A., Schweitzer, ES, Olson, JM, Kazantsev, A., Marsh, JL,
Thompson, LM, 2006. Mutant huntingtin alters MAPK signaling pathways in PC12 and
striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity. Hum. Mol …
expanded polyglutamine repeat within the protein Huntingtin (Htt). We previously reported
that mutant Htt expression activates the ERK1/2 and JNK pathways [Apostol, BL, Illes, K.,
Pallos, J., Bodai, L., Wu, J., Strand, A., Schweitzer, ES, Olson, JM, Kazantsev, A., Marsh, JL,
Thompson, LM, 2006. Mutant huntingtin alters MAPK signaling pathways in PC12 and
striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity. Hum. Mol …
