The ras oncogenes in human lung cancer 1− 3
S Rodenhuis, J SLEBOS - Am. Rev. Respir. Dis, 1990 - atsjournals.org
S Rodenhuis, J SLEBOS
Am. Rev. Respir. Dis, 1990•atsjournals.orgThe three well-characterized genes of the ras gene family H-ras, K-ras, and N-ras, code for
closely related 21-kDproteins that have a role In the transduction of growth signals. The ras
proteins acquire transforming potential when a point mutation In the gene leads to
replacement of an amino acid In one of the critical positions 12, 13, or 61. Overexpresslon of
the normal protein, usually associated with gane amplification, can havesimilar effeCt8.
closely related 21-kDproteins that have a role In the transduction of growth signals. The ras
proteins acquire transforming potential when a point mutation In the gene leads to
replacement of an amino acid In one of the critical positions 12, 13, or 61. Overexpresslon of
the normal protein, usually associated with gane amplification, can havesimilar effeCt8.
Summary
The three well-characterized genes of the ras gene family H-ras, K-ras, and N-ras, code for closely related 21-kDproteins that have a role In the transduction of growth signals. The ras proteins acquire transforming potential when a point mutation In the gene leads to replacement of an amino acid In one of the critical positions 12, 13, or 61. Overexpresslon of the normal protein, usually associated with gane amplification, can havesimilar effeCt8.
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