Ca2+/calmodulin-dependent protein kinase II in heart failure
H Schulman, ME Anderson - Drug Discovery Today: Disease Mechanisms, 2010 - Elsevier
Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) is now recognized to play a
central role in myocardial biology and disease. CaMKII appears to grade myocardial
performance and regulate heart rate by catalyzing the phosphorylation of major proteins
involved in cardiac excitation-contraction coupling. Under pathological stress, CaMKII
activates hypertrophic and inflammatory transcriptional pathways and promotes apoptosis.
Animal studies suggest that CaMKII inhibition may be an effective approach for treating …
central role in myocardial biology and disease. CaMKII appears to grade myocardial
performance and regulate heart rate by catalyzing the phosphorylation of major proteins
involved in cardiac excitation-contraction coupling. Under pathological stress, CaMKII
activates hypertrophic and inflammatory transcriptional pathways and promotes apoptosis.
Animal studies suggest that CaMKII inhibition may be an effective approach for treating …
