Objectives. Tumor heterogeneity can be measured by quantifying variance of nuclear
characteristics by image analysis. Heterogeneity of cell nuclear features correlated with
increased local progression in prostate cancer. In the present study, the influence of tumor
heterogeneity on prostate-specific antigen (PSA) recurrence after radical retropubic
prostatectomy was analyzed and tumor heterogeneity was compared in patients with and
without neoadjuvant hormonal therapy. Methods. Retrospectively, radical prostatectomy …