Genome Scale Identification of Treponema pallidum Antigens
M McKevitt, MB Brinkman, M McLoughlin… - Infection and …, 2005 - Am Soc Microbiol
M McKevitt, MB Brinkman, M McLoughlin, C Perez, JK Howell, GM Weinstock, SJ Norris…
Infection and immunity, 2005•Am Soc MicrobiolAntibody responses for 882 of the 1,039 proteins in the proteome of Treponema pallidum
were examined. Sera collected from infected rabbits were used to systematically identify 106
antigenic proteins, including 22 previously identified antigens and 84 novel antigens.
Additionally, sera collected from rabbits throughout the course of infection demonstrated a
progression in the breadth and intensity of humoral immunoreactivity against a
representative panel of T. pallidum antigens.
were examined. Sera collected from infected rabbits were used to systematically identify 106
antigenic proteins, including 22 previously identified antigens and 84 novel antigens.
Additionally, sera collected from rabbits throughout the course of infection demonstrated a
progression in the breadth and intensity of humoral immunoreactivity against a
representative panel of T. pallidum antigens.
Abstract
Antibody responses for 882 of the 1,039 proteins in the proteome of Treponema pallidum were examined. Sera collected from infected rabbits were used to systematically identify 106 antigenic proteins, including 22 previously identified antigens and 84 novel antigens. Additionally, sera collected from rabbits throughout the course of infection demonstrated a progression in the breadth and intensity of humoral immunoreactivity against a representative panel of T. pallidum antigens.
American Society for Microbiology