TGF-β differentially regulates TH2 cytokine-induced eotaxin and eotaxin-3 release by human airway smooth muscle cells
S Zuyderduyn, PS Hiemstra, KF Rabe - Journal of allergy and clinical …, 2004 - Elsevier
BACKGROUND: Human airway smooth muscle cells (HASMs) are involved in the
pathogenesis of asthma. By producing chemokines, HASMs play a role in the inflammatory
processes observed in this disease. Eotaxin, eotaxin-2, and eotaxin-3 are important
chemoattractants for eosinophils, and these chemokines are expressed during different
phases of the allergic reaction. TH2 cytokines and TGF-β can be found in increased levels in
patients with asthma, and these cytokines may be involved in the regulation of chemokine …
pathogenesis of asthma. By producing chemokines, HASMs play a role in the inflammatory
processes observed in this disease. Eotaxin, eotaxin-2, and eotaxin-3 are important
chemoattractants for eosinophils, and these chemokines are expressed during different
phases of the allergic reaction. TH2 cytokines and TGF-β can be found in increased levels in
patients with asthma, and these cytokines may be involved in the regulation of chemokine …
