Helicobacter pylori Virulence and Genetic Geography
A Covacci, JL Telford, GD Giudice, J Parsonnet… - Science, 1999 - science.org
Science, 1999•science.org
Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is
responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by
horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence.
The infection is now treated with antibiotics, and vaccines are in preparation. The
geographic distribution suggests coevolution of man and Helicobacter pylori.
responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by
horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence.
The infection is now treated with antibiotics, and vaccines are in preparation. The
geographic distribution suggests coevolution of man and Helicobacter pylori.
Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation. The geographic distribution suggests coevolution of man and Helicobacter pylori.
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