Loss of cyclin D1 does not inhibit the proliferative response of mouse liver to mitogenic stimuli
GM Ledda-Columbano, M Pibiri, D Concas, C Cossu… - Hepatology, 2002 - Elsevier
Cyclin D1 is considered to play a critical role in the progression from G1 to S phase of the
cell cycle, and its overexpression is seen in many human tumors. However, previous studies
in cell lines have shown that cyclin D1 is not sufficient to trigger cell replication. To directly
test the role of cyclin D1 in the progression of the cell cycle, we have examined the
proliferative response of hepatocytes to the hepatomitogen 1, 4-bis [2-(3, 5-
dichloropyridyloxy)] benzene (TCPOBOP) in mice with homozygous disruption of the cyclin …
cell cycle, and its overexpression is seen in many human tumors. However, previous studies
in cell lines have shown that cyclin D1 is not sufficient to trigger cell replication. To directly
test the role of cyclin D1 in the progression of the cell cycle, we have examined the
proliferative response of hepatocytes to the hepatomitogen 1, 4-bis [2-(3, 5-
dichloropyridyloxy)] benzene (TCPOBOP) in mice with homozygous disruption of the cyclin …