[HTML][HTML] Transcriptional Activation of the Human ucp1 Gene in a Rodent Cell Line: SYNERGISM OF RETINOIDS, ISOPROTERENOL, AND THIAZOLIDINEDIONE IS …
M del Mar Gonzalez-Barroso, C Pecqueur… - Journal of Biological …, 2000 - ASBMB
Uncoupling protein 1 (UCP1) is uniquely expressed in brown adipocytes and generates
heat production by uncoupling respiration from ATP synthesis. The activatory effects of
norepinephrine and retinoic acid (RA) on rodent ucp1gene transcription have been well
characterized. These effects are mediated by a 211-base pair (bp) enhancer which is also
sufficient to restrict expression to brown adipose tissue. The molecular mechanisms
controlling the transcription of the human ucp1 gene are unknown. In order to study the …
heat production by uncoupling respiration from ATP synthesis. The activatory effects of
norepinephrine and retinoic acid (RA) on rodent ucp1gene transcription have been well
characterized. These effects are mediated by a 211-base pair (bp) enhancer which is also
sufficient to restrict expression to brown adipose tissue. The molecular mechanisms
controlling the transcription of the human ucp1 gene are unknown. In order to study the …
