Subcapsular cell hyperplasia and mast cell infiltration in the adrenal cortex of mice: comparative study in 7 inbred strains
JS Kim, H Kubota, Y Kiuchi, K DOI… - Experimental …, 1997 - jstage.jst.go.jp
JS Kim, H Kubota, Y Kiuchi, K DOI, J SAEGUSA
Experimental animals, 1997•jstage.jst.go.jpSubcapsular cell hyperplasia (SCH) in the adrenal cortex of aged mice (13—15 months old)
was frequent in both sexes of BALB/c, 63H/He, DBA/2J and IOl/Jic mice and in the females
of A/J and C57BL/6, although the incidence and severity of SCH were considerably different
among mouse strains. Mast cells were closely associated with SCH in the A/J, BALB/c,
CS7BL/6, DBA/2J and IOI/Jic mice, but not in the CBH/He strain. Compared with other
strains, lQl/Jic mice had a significantly larger number of mast cells in the adrenal glands. Our …
was frequent in both sexes of BALB/c, 63H/He, DBA/2J and IOl/Jic mice and in the females
of A/J and C57BL/6, although the incidence and severity of SCH were considerably different
among mouse strains. Mast cells were closely associated with SCH in the A/J, BALB/c,
CS7BL/6, DBA/2J and IOI/Jic mice, but not in the CBH/He strain. Compared with other
strains, lQl/Jic mice had a significantly larger number of mast cells in the adrenal glands. Our …
Abstract
Subcapsular cell hyperplasia (SCH) in the adrenal cortex of aged mice (13—15 months old) was frequent in both sexes of BALB/c, 63H/He, DBA/2J and IOl/Jic mice and in the females of A/J and C57BL/6, although the incidence and severity of SCH were considerably different among mouse strains. Mast cells were closely associated with SCH in the A/J, BALB/c, CS7BL/6, DBA/2J and IOI/Jic mice, but not in the CBH/He strain. Compared with other strains, lQl/Jic mice had a significantly larger number of mast cells in the adrenal glands. Our findings suggest that mast cells may participate in the development of SCH, and IOl/Jic would be suitable for studying the pathogenesis of SCH and the role of mast cells in this lesion.
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