Mosaicism in the skin: the importance of mild or minimal skin lesions
C Has - Archives of dermatology, 2011 - jamanetwork.com
OWING TO ITS ACCESSIBILITY, THE SKIN OF-fers unique opportunities to observe and
study the phenomenon of mosaicism. This seems to be more frequent than we used to
believe. However, one must be aware of it to “see” it. The term mosaicism refers to the
presence in an individual of 2 (or more) genetically distinct cell populations derived from the
same zygote. 1 In the 1980s, excellent clinicians provided clinical observations on mosaic
patterns in the skin. It was Rudolf Happle, MD, who postulated new genetic concepts on …
study the phenomenon of mosaicism. This seems to be more frequent than we used to
believe. However, one must be aware of it to “see” it. The term mosaicism refers to the
presence in an individual of 2 (or more) genetically distinct cell populations derived from the
same zygote. 1 In the 1980s, excellent clinicians provided clinical observations on mosaic
patterns in the skin. It was Rudolf Happle, MD, who postulated new genetic concepts on …