IgG4 subclass in malignant melanoma
M Daveau, JP Fischer, L Rivat, C Rivat… - Journal of the …, 1977 - academic.oup.com
M Daveau, JP Fischer, L Rivat, C Rivat, C Ropartz, HH Peter, JP Cesarini, FM Kourilsky
Journal of the National Cancer Institute, 1977•academic.oup.comThree hundred and ninety-seven sera from 185 melanoma patients were studied. These
sera were classified into three groups according to stage of disease. An alteration in the
level of the IgG4 subclass was found. It was related to the dissemination of disease. The
percentage of abnormalities (either increased or decreased levels of IgG4) was more
frequent in patients with stage II and III diseases (55 and 53%, respectively) than in patients
with stage I (19%). The higher frequencies of high titers of IgG4 were essentially detected in …
sera were classified into three groups according to stage of disease. An alteration in the
level of the IgG4 subclass was found. It was related to the dissemination of disease. The
percentage of abnormalities (either increased or decreased levels of IgG4) was more
frequent in patients with stage II and III diseases (55 and 53%, respectively) than in patients
with stage I (19%). The higher frequencies of high titers of IgG4 were essentially detected in …
Abstract
Three hundred and ninety-seven sera from 185 melanoma patients were studied. These sera were classified into three groups according to stage of disease. An alteration in the level of the IgG4 subclass was found. It was related to the dissemination of disease. The percentage of abnormalities (either increased or decreased levels of IgG4) was more frequent in patients with stage II and III diseases (55 and 53%, respectively) than in patients with stage I (19%). The higher frequencies of high titers of IgG4 were essentially detected in advanced disease. The biologic significance of the increase of IgG4 in melanoma remains obscure. The increase may be related to the development of facilitating antibodies of the IgG4 subclass.
Oxford University Press