Topical treatment of acne vulgaris: retinoids and cutaneous irritation
JJ Leyden - Journal of the American Academy of Dermatology, 1998 - jaad.org
April 1998 S2 Leyden microsponges. The microsponge is a novel delivery system for the
controlled release of topical agents and consists of macroporous beads, typically 10 to 25
microns in diameter. Application of the microsponge delivery system to the skin distributes
the active ingredient gradually and has demonstrated the ability to reduce the irritancy of
benzoyl peroxide and tretinoin formulations. Two studies of a 0.1% tretinoin formulation
incorporating the microsponge delivery system have been reported recently. 15 In the first, a …
controlled release of topical agents and consists of macroporous beads, typically 10 to 25
microns in diameter. Application of the microsponge delivery system to the skin distributes
the active ingredient gradually and has demonstrated the ability to reduce the irritancy of
benzoyl peroxide and tretinoin formulations. Two studies of a 0.1% tretinoin formulation
incorporating the microsponge delivery system have been reported recently. 15 In the first, a …