Does over-expression of transforming growth factor-beta account for the increased morbidity in African-Americans?: possible clinical study and therapeutic …
AR Eiser - Medical Hypotheses, 2010 - Elsevier
African-Americans experience an excessive prevalence of a number of apparently disparate
disorders that all appear to be, at least in part, mediated by the over-expression or activation
of transforming growth factor-beta (TGF-beta) signaling pathways, and that certain
genotypes including the codon 10 polymorphism occur more commonly among African-
Americans and appears to predispose to these disorders. These disorders, fibrosing in
nature, include hypertension, focal glomerulosclerosis, diabetic nephropathy, end stage …
disorders that all appear to be, at least in part, mediated by the over-expression or activation
of transforming growth factor-beta (TGF-beta) signaling pathways, and that certain
genotypes including the codon 10 polymorphism occur more commonly among African-
Americans and appears to predispose to these disorders. These disorders, fibrosing in
nature, include hypertension, focal glomerulosclerosis, diabetic nephropathy, end stage …
