[HTML][HTML] Huntingtin-associated protein-1 deficiency in orexin-producing neurons impairs neuronal process extension and leads to abnormal behavior in mice
YF Lin, X Xu, A Cape, S Li, XJ Li - Journal of biological chemistry, 2010 - ASBMB
Huntingtin-associated protein-1 (Hap1) is a neuronal protein that associates with huntingtin,
the Huntington disease protein. Although Hap1 and huntingtin are known to be involved in
intracellular trafficking, whether and how the impairment of Hap1-associated trafficking leads
to neurological pathology and symptoms remain to be seen. As Hap1 is enriched in
neuronal cells in the brain, addressing this issue is important in defining the role of defective
intracellular trafficking in the selective neuropathology associated with Hap1 dysfunction …
the Huntington disease protein. Although Hap1 and huntingtin are known to be involved in
intracellular trafficking, whether and how the impairment of Hap1-associated trafficking leads
to neurological pathology and symptoms remain to be seen. As Hap1 is enriched in
neuronal cells in the brain, addressing this issue is important in defining the role of defective
intracellular trafficking in the selective neuropathology associated with Hap1 dysfunction …