Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure
M Artwohl, A Lindenmair, M Roden, WK Waldhäusl… - Atherosclerosis, 2009 - Elsevier
OBJECTIVE: Plasma free fatty acid (FFA) concentrations are increased in states of insulin
resistance. Therefore, this study evaluated apoptosis and underlying mechanisms induced
by selected nutritional FFAs, a defined FFA-mix, and human plasma containing high FFA
concentrations in human smooth muscle cells (HSMCs). RESEARCH DESIGN AND
METHODS: HSMCs were incubated (24–72h) with selected FFAs (100–300μmol/l), an FFA-
mix (palmitic-/stearic-/oleic-/linoleic-/α-linolenic acid= 2.6/1/3.6/9/1; 300–900μmol/l), or with …
resistance. Therefore, this study evaluated apoptosis and underlying mechanisms induced
by selected nutritional FFAs, a defined FFA-mix, and human plasma containing high FFA
concentrations in human smooth muscle cells (HSMCs). RESEARCH DESIGN AND
METHODS: HSMCs were incubated (24–72h) with selected FFAs (100–300μmol/l), an FFA-
mix (palmitic-/stearic-/oleic-/linoleic-/α-linolenic acid= 2.6/1/3.6/9/1; 300–900μmol/l), or with …