Despite intensive glucose-lowering treatment and advanced therapies for cardiovascular
risk factors, such as hypertension and dyslipidaemia, diabetes mellitus with its macro-and
microvascular complications remains a major health problem. Especially diabetic
nephropathy is a leading cause of morbidity and mortality, and its prevalence is increasing.
Peroxisome proliferator-activated receptor-α (PPAR-α), a member of a large nuclear
receptor superfamily, is expressed in several tissues including the kidney. Recently …