[HTML][HTML] Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl–self-exchange activity
MD Parker, R Musa-Aziz, JD Rojas, I Choi… - Journal of Biological …, 2008 - ASBMB
The SLC4A10 gene product, commonly known as NCBE, is highly expressed in rodent brain
and has been characterized by others as a Na+-driven Cl-HCO 3 exchanger. However,
some of the earlier data are not consistent with Na+-driven Cl-HCO 3 exchange activity. In
the present study, northern blot analysis showed that, also in humans, NCBE transcripts are
predominantly expressed in brain. In some human NCBE transcripts, splice cassettes A
and/or B, originally reported in rats and mice, are spliced out. In brain cDNA, we found …
and has been characterized by others as a Na+-driven Cl-HCO 3 exchanger. However,
some of the earlier data are not consistent with Na+-driven Cl-HCO 3 exchange activity. In
the present study, northern blot analysis showed that, also in humans, NCBE transcripts are
predominantly expressed in brain. In some human NCBE transcripts, splice cassettes A
and/or B, originally reported in rats and mice, are spliced out. In brain cDNA, we found …