[HTML][HTML] Advanced glycation end products (AGEs) induce apoptosis via a novel pathway: involvement of Ca2+ mediated by interleukin-8 protein
S Mahali, N Raviprakash, PB Raghavendra… - Journal of Biological …, 2011 - ASBMB
Advanced glycation end products (AGEs) accumulate in diabetic patients due to high blood
glucose levels and cause multiple deleterious effects. In this study, we provide evidence that
the AGE increased cell death, one such deleterious effect. Methyl glyoxal-coupled human
serum albumin (AGE-HSA) induced transcription factors such as NF-κB, NF-AT, and AP-1.
AGE acts through its cell surface receptor, RAGE, and degranulates vesicular contents
including interleukin-8 (IL-8). The number of RAGEs, as well as the amount of NF-κB …
glucose levels and cause multiple deleterious effects. In this study, we provide evidence that
the AGE increased cell death, one such deleterious effect. Methyl glyoxal-coupled human
serum albumin (AGE-HSA) induced transcription factors such as NF-κB, NF-AT, and AP-1.
AGE acts through its cell surface receptor, RAGE, and degranulates vesicular contents
including interleukin-8 (IL-8). The number of RAGEs, as well as the amount of NF-κB …