[HTML][HTML] Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3, 4, 5-trisphosphate
X Gan, J Wang, B Su, D Wu - Journal of Biological Chemistry, 2011 - ASBMB
mTORC2 (mammalian target of rapamycin complex 2) plays important roles in signal
transduction by regulating an array of downstream effectors, including protein kinase AKT.
However, its regulation by upstream regulators remains poorly characterized. Although
phosphatidylinositol 3, 4, 5-trisphosphate (PtdIns (3, 4, 5) P 3) is known to regulate the
phosphorylation of AKT Ser 473, the hydrophobic motif (HM) site, by mTORC2, it is not clear
whether PtdIns (3, 4, 5) P 3 can directly regulate mTORC2 kinase activity. Here, we used two …
transduction by regulating an array of downstream effectors, including protein kinase AKT.
However, its regulation by upstream regulators remains poorly characterized. Although
phosphatidylinositol 3, 4, 5-trisphosphate (PtdIns (3, 4, 5) P 3) is known to regulate the
phosphorylation of AKT Ser 473, the hydrophobic motif (HM) site, by mTORC2, it is not clear
whether PtdIns (3, 4, 5) P 3 can directly regulate mTORC2 kinase activity. Here, we used two …