Role of EGF receptor activation in angiotensin II–induced renal epithelial cell hypertrophy
J Chen, JK Chen, EG Neilson… - Journal of the American …, 2006 - journals.lww.com
For determination of the molecular mechanisms underlying the induction of epithelial cell
hypertrophy by angiotensin II (Ang II), a well-characterized porcine renal proximal tubular
cell line LLCPKcl4, which does not express endogenous Ang II receptor subtypes, was
transfected with cDNA encoding Ang II subtype 1 receptor (AT1R/Cl4). Ang II transactivated
the EGF receptor (EGFR) in these AT1R/Cl4 cells, which was blocked by the selective AT1R
antagonist losartan but not by the selective AT2R antagonist PD123319. Ang II did not …
hypertrophy by angiotensin II (Ang II), a well-characterized porcine renal proximal tubular
cell line LLCPKcl4, which does not express endogenous Ang II receptor subtypes, was
transfected with cDNA encoding Ang II subtype 1 receptor (AT1R/Cl4). Ang II transactivated
the EGF receptor (EGFR) in these AT1R/Cl4 cells, which was blocked by the selective AT1R
antagonist losartan but not by the selective AT2R antagonist PD123319. Ang II did not …