[HTML][HTML] Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells
JK Chen, JR Falck, KM Reddy, J Capdevila… - Journal of Biological …, 1998 - ASBMB
In our present studies utilizing a well characterized proximal tubule cell line, LLCPKcl4, we
determined that all four EET regioisomers (5, 6-EET, 8, 9-EET, 11, 12-EET, and 14, 15-EET)
stimulated [3 H] thymidine incorporation, with 14, 15-EET being the most potent. In contrast,
no mitogenic effects were seen with arachidonic acid, other cP450 arachidonate metabolites
(12R-hydroxyeicosatetraenoic acid (12R-HETE), 14, 15-dihydroxyeicosatrienoic acid (14, 15-
DHET), or 20-HETE), or lipoxygenase metabolites (5S-HETE, leukotriene B 4, or lipoxin A4) …
determined that all four EET regioisomers (5, 6-EET, 8, 9-EET, 11, 12-EET, and 14, 15-EET)
stimulated [3 H] thymidine incorporation, with 14, 15-EET being the most potent. In contrast,
no mitogenic effects were seen with arachidonic acid, other cP450 arachidonate metabolites
(12R-hydroxyeicosatetraenoic acid (12R-HETE), 14, 15-dihydroxyeicosatrienoic acid (14, 15-
DHET), or 20-HETE), or lipoxygenase metabolites (5S-HETE, leukotriene B 4, or lipoxin A4) …