Cytotoxic T cells isolated from ovarian malignant ascites recognize a peptide derived from the HER-2/neu proto-oncogene
CG Ioannides, B Fisk, D Fan, WE Biddison… - Cellular …, 1993 - Elsevier
Abstract The HER-2/neu proto-oncogene encodes a transmembrane receptor protein whose
expression is enhanced in a number of breast and ovarian tumors and correlates with tumor
aggressiveness, suggesting that it may play an important role in tumor growth. Recent
evidence suggests that HER-2/neu may be a potential candidate for targeted immune
intervention. In this report we show that cytotoxic T lymphocytes (CTL) expanded from tumor-
associated lymphocytes with HLA-A2+ and HER-2/neu+ tumors can specifically recognize …
expression is enhanced in a number of breast and ovarian tumors and correlates with tumor
aggressiveness, suggesting that it may play an important role in tumor growth. Recent
evidence suggests that HER-2/neu may be a potential candidate for targeted immune
intervention. In this report we show that cytotoxic T lymphocytes (CTL) expanded from tumor-
associated lymphocytes with HLA-A2+ and HER-2/neu+ tumors can specifically recognize …