Controlled induction of a pseudarthrosis: a study using a rodent model
LJ Harrison, JL Cunningham, L Strömberg… - … of orthopaedic trauma, 2003 - journals.lww.com
LJ Harrison, JL Cunningham, L Strömberg, AE Goodship
Journal of orthopaedic trauma, 2003•journals.lww.comObjectives This study aimed to test the hypothesis that under standardized mechanical and
biologic conditions, the process of indirect bone repair in a rodent species could be
manipulated to form a reproducible, atrophic, fibrous pseudarthrosis. Design The model
used comprised a mid-diaphyseal, transverse osteotomy in the rat femur, stabilized via a
precision miniature external fixator, a constant axial fixation stiffness being defined by a
specific frame geometry.
biologic conditions, the process of indirect bone repair in a rodent species could be
manipulated to form a reproducible, atrophic, fibrous pseudarthrosis. Design The model
used comprised a mid-diaphyseal, transverse osteotomy in the rat femur, stabilized via a
precision miniature external fixator, a constant axial fixation stiffness being defined by a
specific frame geometry.
Abstract
Objectives
This study aimed to test the hypothesis that under standardized mechanical and biologic conditions, the process of indirect bone repair in a rodent species could be manipulated to form a reproducible, atrophic, fibrous pseudarthrosis.
Design
The model used comprised a mid-diaphyseal, transverse osteotomy in the rat femur, stabilized via a precision miniature external fixator, a constant axial fixation stiffness being defined by a specific frame geometry.
Lippincott Williams & Wilkins