[HTML][HTML] Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis
C Morrison, S Mancini, J Cipollone… - Journal of Biological …, 2011 - ASBMB
Dynamic reciprocal interactions between a tumor and its microenvironment impact both the
establishment and progression of metastases. These interactions are mediated, in part,
through proteolytic sculpting of the microenvironment, particularly by the matrix
metalloproteinases, with both tumors and stroma contributing to the proteolytic milieu.
Because bone is one of the predominant sites of breast cancer metastases, we used a co-
culture system in which a subpopulation of the highly invasive human breast cancer cell line …
establishment and progression of metastases. These interactions are mediated, in part,
through proteolytic sculpting of the microenvironment, particularly by the matrix
metalloproteinases, with both tumors and stroma contributing to the proteolytic milieu.
Because bone is one of the predominant sites of breast cancer metastases, we used a co-
culture system in which a subpopulation of the highly invasive human breast cancer cell line …
