[HTML][HTML] NF-κB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox
J Anrather, G Racchumi, C Iadecola - Journal of Biological Chemistry, 2006 - ASBMB
The superoxide-generating phagocytic NADPH oxidase is an important component of the
innate immune response against microbial agents, and is involved in shaping the cellular
response to a variety of physiological and pathological signals. One of the downstream
targets of NADPH oxidase-derived radicals is the ubiquitous transcription factor NF-κB,
which controls the expression of a large array of genes involved in immune function and cell
survival. Here we show that NF-κB itself is a key factor in controlling NADPH oxidase …
innate immune response against microbial agents, and is involved in shaping the cellular
response to a variety of physiological and pathological signals. One of the downstream
targets of NADPH oxidase-derived radicals is the ubiquitous transcription factor NF-κB,
which controls the expression of a large array of genes involved in immune function and cell
survival. Here we show that NF-κB itself is a key factor in controlling NADPH oxidase …